Hif sumo

WebWe assessed the effect of deSUMOylation on HIF-1α activity in HCC cells using HIF-1α SUMOylated site mutants, K391R and K477R.26 SUMOylation of exogenous HIF-1α was detected through cotransfection of haemagglutinin (HA)-SUMO-1 and regulation of G-protein signaling domain (RGS)-HIF-1α wild-type (WT) or its mutants (RGS-HIF-1α K391R; RGS … Web26 de nov. de 2024 · Thermal stimulation upregulated the expression of Hsp70 and promoted SUMO modification of HIF-1α, ultimately promoting the proliferation and …

Dynamic regulation of HIF1Α stability by SUMO2/3 and …

Web3 de jan. de 2024 · Collectively, our results reveal a novel SENP1–USP28–HIF-1α positive feedback loop to maximize the concentration of HIF-1a protein and amplify its ... Stalla GK, Holsboer F, Arzt E. RSUME, a small RWD-containing protein, enhances SUMO conjugation and stabilizes HIF-1alpha during hypoxia. Cell. 2007;131:309–23. Article ... Web8 de fev. de 2008 · Introduction. The post-translational modification of proteins with the ubiquitin-like SUMO modifier has an important regulatory function in many cellular processes, including DNA repair, cell-cycle progression and transcription (Muller et al, 2004; Hay, 2005).Human cells express three forms of SUMO—SUMO1, SUMO2 and SUMO3. ipr infusion pumps https://perfectaimmg.com

SUMO-Specific Protease 1 Is Essential for Stabilization of HIF1α ...

WebIn addition, the present data suggest that SUMO‑1 regulated HIF‑1α in response to hypoxia (gene silencing and overexpression). Finally, the co‑immunoprecipitation assays suggest … Web30 de out. de 2024 · Post-translational modification by SUMO (small ubiquitin-like modifier) proteins has been shown to regulate a variety of functions of proteins, including protein stability, chromatin organization, transcription, DNA repair, subcellular localization, protein–protein interactions, and protein homeostasis. SENP (sentrin/SUMO-specific … Web25 de out. de 2024 · HIF proteins function as transcription factors composed of a heterodimer of α (HIF1α or HIF2α) and β (HIF1β) subunits. pVHL is a ubiquitin E3 ligase … orc 3959

Frontiers Non-Canonical Mechanisms Regulating Hypoxia …

Category:The role of Hypoxia-Inducible Factor-1alpha and its signaling in ...

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Hif sumo

SUMO-Specific Protease 1 Is Essential for Stabilization of HIF1α ...

Web1 de abr. de 2016 · We next examined the functional consequence of HIF1A SUMOylation by overexpressing SUMO2/3 in JEG3 cells cultured at 3% and 21% O 2 in the presence … Web14 de mai. de 2015 · SUMO-1, HIF-1α and VEGF levels in rat pulmonary arteries following exposure to hypoxia. The mRNA levels of SUMO-1, HIF-1α and VEGF in pulmonary arteries from control and hypoxia-treated rats were assessed using in situ hybridization and RT-PCR (). SUMO-1 mRNA levels were extremely low in the control group (), increased by day 3 …

Hif sumo

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Web2 de nov. de 2007 · SUMOylation is a dynamic process, catalyzed by SUMO-specific ligases and reversed by Sentrin/SUMO-specific proteases (SENPs). The physiologic …

Web20 de jun. de 2024 · Interestingly, some HIF hydroxylases can also regulate metabolic processes through mechanisms that are at least in part independent of HIF 101,102,103,104. Fig. 3: HIF-mediated adaptations of ... Web31 de ago. de 2024 · Regulatory axis of VHL, SENP1, and SUMO-enhancer RSUME is essential for the modulation of HIF activity in response to hypoxia. Hypoxia induces SENP1-mediated deSUMOylation of HIFs, promoting the stabilization and transactivation of both HIF1α and HIF2α by protecting them from VHL-mediated proteasomal degradation [ 44 , …

WebFurthermore, results obtained from CO-IP had suggested that SUMO-1 interacted with HIF-1α, and prevented its ubiquitination and degradation in HTECs by sumoylating. … Web11 de jun. de 2012 · As we had previously found that the SUMO protease SENP3 accumulated in response to a mild increase in ROS and could specifically deconjugate SUMO2/3 from p300 thus promoting p300 binding with HIF ...

Web18 de jan. de 2008 · HIF is able to direct transcription from either of two transactivation domains, ... enhances SUMO conjugation and stabilizes HIF-1alpha during hypoxia. Cell 2007; 131: 309–323.

Web2 de nov. de 2007 · SUMOylation is a dynamic process, catalyzed by SUMO-specific ligases and reversed by Sentrin/SUMO-specific proteases ... RACK1 competes with HSP90 for binding to HIF-1alpha and is required for O(2)-independent and HSP90 inhibitor-induced degradation of HIF-1alpha. Mol. Cell, 25 (2007), pp. 207-217. ipr internship in noidaWeb31 de jul. de 2014 · The ubiquitin-like SUMO (small ubiquitin-related modifier) system is a post-translational protein modification pathway in eukaryotes [ [ 1 ], [ 2 ]]. SUMOylation is a highly dynamic process, where deconjugation (deSUMOylation) is catalyzed by a family of cysteine proteases, termed SUMO-specific proteases or SUMO isopeptidases. orc 3eWeb8 de jan. de 2016 · Abstract. SUMOylation is a ubiquitin-related transient posttranslational modification pathway catalyzing the conjugation of small ubiquitin-like modifier (SUMO) … orc 4109Web18 de abr. de 2024 · Some are able to directly activate TRPV1, e.g., protons, or modulate the channel gating, e.g., prostaglandins and bradykinin 12,49,51, while others can … orc 4101WebHIF-1α was first immunoprecipitated ... Although it is reported that HIF-1α can be regulated by Sentrin/SUMO-specific protease 1 (SENP1), the effects of SENP1 on HIF-1α is still … orc 3cWeb24 de fev. de 2024 · SUMOylation, the conjugation of small ubiquitin-related modifier protein (SUMO) to a target protein, has been considered to play an essential regulatory role in HIF-1α protein stability [10,11,12]. SUMOylation of HIF-1α promotes recruitment of the modified protein to VHL through a PHD-independent mechanism, leading to ubiquitination and … ipr is the focus on his theoryWeb1 de set. de 2024 · The up-regulation of glucose transporter proteins 1 and 3 (GLUT1 and GLUT3) is a critical characteristic in cancer cells regulated by HIF-1α. GLUT transporter’s main cellular role is to facilitate glucose entry into the cell [73]. Moreover, HIF-1α can up-regulate hexokinase 1 and 2 levels (HK1 and HK2) in tumor cells. orc 4109.02