Cisplatin induced toxicity
WebA major problem besides cisplatin resistance (occurring in nearly one-third of patients) is the greater toxicity of the drug combinations. A synergistic treatment with drug supporting activity could maximize the cytotoxic effects of chemotherapeutic agents on tumor cells while decreasing the dosage of each drug to potentially reduce toxicity. WebNov 26, 2024 · Cisplatin-Induced Toxicity . Cisplatin, cis- diamine-dichloro-platinum (CDDP) is one of the most used chemotherapy drugs because it is effective against different types of tumors. Cisplatin is an alkylating agent which is cell-cycle-phase nonspecific. It can bond to proteins, RNA and DNA, inhibiting DNA synthesis and cell cycle and it can also ...
Cisplatin induced toxicity
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WebMay 9, 2024 · A general discussion of the clinical presentation, pathogenesis, diagnosis, differential diagnosis, and management of antineoplastic agent-induced pulmonary … WebApr 14, 2024 · Among the extracellular vesicles, apoptotic bodies (ABs) are only formed during the apoptosis and perform a relevant role in the pathogenesis of different …
WebCisplatin-induced early-onset ototoxicity is linked to hearing loss. The mechanism by which cisplatin causes ototoxicity remains unclear. The purpose of this study was to identify the involvement of receptor-interacting protein kinase (RIP)3-dependent necroptosis in cisplatin-induced ototoxicity in vitro and in vivo. Sprague–Dawley rats (SD, 8 week) … WebMay 8, 2024 · Cisplatin chemotherapy is used alone or in combination to treat a variety of cancers, including ovarian, testicular, lung, cervical, bladder, head and neck, and gastric cancers as well as lymphoma, melanoma, and more. Although it offers options for many cancer types, its use may result in nephrotoxicity, a dose-limiting side effect.
WebDec 16, 2024 · Cisplatin (CDDP; cis-dichlorodiammine platinum [II]) is a non-specific drug of the cell cycle with strong cytotoxicity and broad-spectrum antitumor effects; it is widely used in urogenital system tumors, malignant lymphoma, breast cancer, head and neck cancer, non-small cell lung cancer, etc. ( 1 – 3) Cisplatin-induced nephrotoxicity is … WebApr 28, 2024 · Cisplatin-Induced Reproductive Toxicity and Oxidative Stress: Ameliorative Effect of Kinetin . Authors Rania Abdel-Latif 1 , Moustafa Fathy 2 , Hend Ali Anwar 2 , Muhammad Naseem 3 4 , Thomas Dandekar 4 , Eman M Othman 2 4 Affiliations 1 Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Minia, …
WebFeb 11, 2024 · Cisplatin is a cytotoxic drug that triggers several toxicities. However, nephrotoxicity and ototoxicity remain major clinical limitations. The aim of our study was …
WebApr 14, 2024 · Among the extracellular vesicles, apoptotic bodies (ABs) are only formed during the apoptosis and perform a relevant role in the pathogenesis of different diseases. Recently, it has been demonstrated that ABs from human renal proximal tubular HK-2 cells, either induced by cisplatin or by UV light, can lead to further apoptotic death in … diary of a wimpy kid the long haul actorsWebBackground and propose: Cisplatin is a cytotoxic drug that triggers several toxicities. However, nephrotoxicity and ototoxicity remain major clinical limitations. The aim of our … cities skylines missing assets fixWebJun 22, 2024 · Cisplatin (CisP) is a chemotherapeutic agent used to treat head and neck and lung cancer in adults and over 15 different pediatric cancers. Despite its known … cities skylines mixed zoningWebBackground and propose: Cisplatin is a cytotoxic drug that triggers several toxicities. However, nephrotoxicity and ototoxicity remain major clinical limitations. The aim of our study was to evaluate the incidence of chemotherapy toxicity induced by cisplatin and to analyze the influence of risk factors in the Tunisian population. diary of a wimpy kid the long haul fandomWebOxidative stress plays a pivotal role in cisplatin-induced renal damage and several dietary antioxidants have been reported to ameliorate this secondary effect. Relevant findings on the protective effects of these antioxidant agents in cisplatin-induced nephrotoxicity are summarized in this paper. cities skylines mixed use zoning modWebFeb 2, 2024 · 5.1 Cisplatin-Induced Nephrotoxicity. Cisplatin, a potent chemotherapeutic agent used for treating various types of solid organ tumors, is limited by its serious side effects in clinical application (Yu et al., 2024; Deng et al., 2024). Cisplatin can cause an increase in the expression of NF-κB and TNF-α in the liver and kidney (Park et al., 2024 diary of a wimpy kid the long haul disneyWebOct 26, 2005 · Cisplatin-induced cytotoxicity was determined by reduction of 3- (4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) as described previously ( Chen and Cederbaum, 1998 ). Measurement of intracellular GSH. Reduced glutathione (GSH) was assayed using a modified method of Hissin and Hilf (1976). diary of a wimpy kid: the long haul book